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WADA Prohibition Syn-AKE is not currently listed on the World Anti-Doping Agency (WADA) Prohibited List: Not prohibited for competitive athletes in topical cosmetic applications No known ergogenic or performance-enhancing effects relevant to sport Neuromuscular effects are localized and cosmetic rather than systemic No detection methods or testing protocols established Cosmetic Ingredient Review Status The Cosmetic Ingredient Review (CIR) Expert Panel has not formally evaluated Syn-AKE: No independent CIR safety assessment published as of current date Safety profile based primarily on manufacturer data Anecdotal reports of skin reactions (swelling, redness, itching, stinging) in some users Recommended patch testing before widespread facial application Research Classification: Syn-AKE is available as a cosmetic ingredient for formulation research and topical product development

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[DOI] [PubMed] [Google Scholar] 47.Steinhoff M, et al